منابع مشابه
Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses.
Bioisosteric deaza analogues of 6-methyl-9-β-D-ribofuranosylpurine, a hydrophobic analogue of adenosine, were synthesized and evaluated for antiviral activity. Whereas the 1-deaza and 3-deaza analogues were essentially inactive in plaque assays of infectivity, a novel 7-deaza-6-methyl-9-β-D-ribofuranosylpurine analogue, structurally related to the natural product tubercidin, potently inhibited ...
متن کاملDengue virus infection: predictors for severe dengue.
Dengue virus (DENV) infection is a mosquito born disease that is endemic in all WHO regions, except European region, and may present a broad range of severity. It may appear as an asymptomatic condition, dengue fever (DF), or life threatening forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), or the currently defined severe dengue. Currently there are means to diagno...
متن کاملDengue Infection in Pregnancy.
While dengue infection is still on the increase in adults in Thailand, it also affects pregnant women, especially pregnant teenagers. This study was designed to investigate dengue infection during pregnancy. Seven cases of dengue infection in pregnant women were admitted to Ban Pong Hospital, Ratchaburi, Thailand, between 2008 and 2012. Dengue infection presented in all pregnancy trimesters. Th...
متن کاملPerinatal Dengue Infection
A case of vertical transmission of dengue infection in the perinatal period is reported. The mother, a term pregnancy, had acute dengue the day before admission. The infant was born at term and developed fever on the fifth day of life which lasted for 5 days. No bleeding or plasma leakage was detected during the course of fever in infant or mother. A liver function test showed elevated SGOT and...
متن کاملMicropower Analogue Building Blocks for Template Matching in Implantable Devices
The design of analogue low power VLSI building block is very important for implantable devices, like cochlear implants and implantable cardioverter deebril-lators(ICD). In this paper we describe the micropower analogue building blocks for implementing the template matcher used for intracardiac electrogram (ICEG) clas-siication and data compression in an ICD. These blocks were fabricated using O...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2010
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd3081